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Related Experiment Videos

Vasoconstriction: a novel activity for low density lipoprotein.

A Sachinidis1, R Locher, T Mengden

  • 1Department of Internal Medicine, University Hospital, Zürich, Switzerland.

Biochemical and Biophysical Research Communications
|August 30, 1989
PubMed
Summary

Low density lipoprotein (LDL) can cause blood vessel constriction. This vasoconstriction is mediated by changes in intracellular calcium and pH, contributing to atherosclerosis.

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Area of Science:

  • Cardiovascular biology
  • Vascular smooth muscle physiology
  • Atherosclerosis research

Background:

  • Low density lipoprotein (LDL) is implicated in atherosclerosis development.
  • Understanding LDL's role in vascular function is crucial for cardiovascular disease research.

Purpose of the Study:

  • To investigate the effects of LDL on vascular contractility.
  • To explore the cellular mechanisms underlying LDL-mediated vasoconstriction.

Main Methods:

  • Thoracic aortic rings from rats were used to measure contractile tension.
  • Cultured rat vascular smooth muscle cells were utilized to assess intracellular calcium and pH changes.
  • Dose-dependent responses to varying LDL concentrations were analyzed.

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Main Results:

  • LDL induced a dose-dependent increase in aortic ring contractile tension.
  • The maximal LDL-induced contraction was about 30% of that caused by norepinephrine.
  • LDL altered intracellular calcium and pH in vascular smooth muscle cells.

Conclusions:

  • Extravascular low density lipoprotein can mediate vasoconstriction.
  • Changes in cytosolic calcium and intracellular pH are key mechanisms in LDL-induced vasoconstriction.
  • These findings contribute to understanding the pathogenesis of atherosclerosis.