Increased Ion Transmission for Differential Ion Mobility Combined with Mass Spectrometry by Implementation of a...

Differential ion mobility spectrometry (DIMS) is capable of separating components of complex mixtures prior to mass spectrometric analysis, thereby increasing signal-to-noise and signal-to-background ratios on millisecond timescales. However, adding a DIMS device to the front end of a mass spectrometer can reduce the signal intensity of subsequent mass spectrometric analysis. This is a result, in part, of ions lost due to inefficient transfer of ions from the DIMS device through the aperture leading into the mass spectrometer. This problem of transferring ions can be at least partially corrected by modifying the front end of the inlet capillary leading to the vacuum of the mass spectrometer. The inner diameter of the ion-sampling end of the inlet capillary was enlarged by drilling into the face. This results in a conical flare at the front end of the capillary, while the other end of the capillary remains unmodified. These flared capillaries allow for a greater number of ions from the DIMS device to be sampled relative to the unmodified standard capillary. Four flare dimensions were tested, differing by the angle between the wall of the flare and the outer wall of the inlet capillary. All flared capillaries showed greater signal intensity than the standard capillary with a DIMS device present without reducing the resolving power. It was also observed that the signal intensity increased as the flare angle decreased. The flared capillary with the smallest flare angle showed greater than a fivefold increase in signal intensity compared with the standard capillary. Graphical Abstract ᅟ.