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Synthesis and anti-inflammatory evaluation of novel paclitaxel analogs
Pei-Pei Xu1, Qing-Feng Li1, Yong-Mei Cui1
1a Department of Chemistry , Innovative Drug Research Center, College of Sciences, Shanghai University , Shanghai 200444 , China.
Abstract:
A series of paclitaxel analogs modified at C-3'-N and C-7 positions were synthesized from baccatin III and their structures were confirmed by 1H-NMR, 13C-NMR, HR-MS. Compound 7e exhibited potent ability to decrease TNFα (tumor necrosis factor α) in the LPS-activated RAW264.7 murine macrophage-like cell line. The preliminary data indicated that the anti-inflammatory effects may be related to MD-2 and Toll-like receptor 4 (TLR4), rather than Toll-like receptor 2 (TLR2).
