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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Replicative Cell Senescence02:15

Replicative Cell Senescence

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Related Experiment Video

Updated: Jan 11, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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Telomerase-active urine-derived stem cells: Regenerative solutions for aging.

Xi Cheng1, Qiao-Yu Fu1, Yun-Ling Zheng2

  • 1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China.

Ageing Research Reviews
|November 14, 2025
PubMed
Summary

Urine-derived stem cells (USCs) offer a promising, non-invasive alternative for regenerative medicine. Their unique telomerase activity aids in combating aging and age-related diseases, overcoming limitations of traditional stem cell therapies.

Keywords:
AgingCell therapyPrecision medicineRegenerative medicineStem cellsTelomeraseUrine-derived stem cells (USCs)

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Area of Science:

  • Regenerative Medicine
  • Geroscience
  • Cell Biology

Background:

  • Aging is a complex process causing pathologies and socioeconomic burdens.
  • Conventional stem cell therapies face limitations: invasive collection, ethical concerns, safety risks, and high costs.
  • Urine-derived stem cells (USCs) present a viable alternative with unique advantages.

Purpose of the Study:

  • To highlight the potential of USCs in regenerative medicine and geroscience.
  • To address the limitations of traditional stem cell sources.
  • To explore the therapeutic benefits of telomerase-active USCs for age-related decline.

Main Methods:

  • Characterization of two distinct USC populations: high and low telomerase activity.
  • Comparison of USCs with bone marrow stem cells, adipose-derived stem cells, and induced pluripotent stem cells (iPSCs).
  • Review of preclinical studies on USC efficacy in age-related disorders.

Main Results:

  • USCs are obtained non-invasively, reducing patient discomfort and ethical issues.
  • Telomerase-active USCs address telomere attrition, a hallmark of aging.
  • USCs exhibit robust proliferation, differentiation potential, and enhanced safety compared to iPSCs, with lower tumorigenicity risk.

Conclusions:

  • USCs, particularly those with high telomerase activity, offer an accessible and promising platform for regenerative medicine.
  • USC-based therapies show potential for mitigating age-related tissue degeneration and functional decline.
  • USCs facilitate personalized medicine through disease modeling and drug discovery.