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Relationship between hepatitis B virus infection and chronic kidney disease in Asian populations: a meta-analysis

Qing-Chun Cai1, Shu-Qi Zhao1, Tong-Dong Shi1

  • 1a Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases , The Second Affiliated Hospital, Chongqing Medical University , Chongqing , PR China.

Renal Failure
|October 21, 2016
PubMed

Insights

Chronic hepatitis B virus (HBV) infection is not associated with an increased risk of developing chronic kidney disease (CKD). This meta-analysis found no link between HBV exposure and CKD prevalence or severity in Asian populations.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Epidemiology

Background:

  • Chronic hepatitis B virus (HBV) infection is a global health concern.
  • Chronic kidney disease (CKD) is a progressive condition affecting kidney function.
  • The potential link between HBV infection and CKD requires thorough investigation.

Purpose of the Study:

  • To evaluate the association between chronic hepatitis B virus (HBV) infection and chronic kidney disease (CKD).
  • To determine if HBV infection independently impacts CKD development in the general population.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases including Embase, PubMed, and China Biological Medicine Database.
  • A meta-analysis synthesized data from six eligible clinical studies, totaling 189,709 individuals.
  • Relative risks of CKD, defined by reduced glomerular filtration rate or proteinuria, were assessed based on HBsAg serologic status.

Main Results:

  • The meta-analysis revealed no statistically significant association between HBsAg seropositive status and the prevalence of CKD (adjusted RR, 1.16; 95% CI, 0.78-1.71; p=0.46).
  • No significant associations were found between positive HBV serologic status and low estimated glomerular filtration rate (eGFR) (adjusted RR, 0.95; 95% CI, 0.72-1.26) or proteinuria (adjusted RR, 1.00; 95% CI, 0.83-1.20).
  • Heterogeneity was noted between studies (Q test p < 0.001), indicating variability in study methodologies or populations.

Conclusions:

  • This meta-analysis concludes that exposure to hepatitis B virus (HBV) is not associated with an increased risk of developing chronic kidney disease (CKD).
  • The findings specifically apply to Asian populations, suggesting no direct etiological link between HBV and CKD in this demographic.
  • Further research may explore potential indirect mechanisms or specific subgroups if necessary.
Abstract

Keywords:
Hepatitis Bglomerular filtration ratekidney diseaseproteinuria

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