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Rh factor is associated with individual radiosensitivity: A cytogenetic study.

Meysam Khosravifarsani¹, Ali Shabestani Monfared², Sajad Borzoueisileh³

¹M.Sc. of Radiobiology and Radiation Protection, MPhil, Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran.

Electronic Physician

|October 21, 2016

Summary

The Rh factor may predict radiosensitivity to ionizing radiation. Rh-positive individuals showed a higher frequency of micronuclei (MN) after irradiation compared to Rh-negative individuals.

Keywords:

CBMN assay Nuclear division index (NDI)Radiosensitivity

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Area of Science:

Radiation biology
Genetics
Medical research

Background:

Radiosensitivity, the body's reaction to ionizing radiation, necessitates personalized treatment in radiotherapy and radiation protection.
Identifying biomarkers for normal tissue side reactions is crucial for patient care.

Purpose of the Study:

To investigate the association between the Rh factor and radiosensitivity.
To determine if the Rh factor can serve as a predictive marker for radiation response.

Main Methods:

An experimental study involving 50 healthy young adults (22-23 years old) with blood group A (25 Rh+ and 25 Rh-) in Babol, Iran.
Peripheral blood samples were analyzed using the cytokinesis-block micronucleus (CBMN) assay to measure the frequency of micronuclei (MN) and nuclear division index (NDI) after gamma irradiation.
Statistical analysis included independent and paired samples t-tests using SPSS version 18.

Main Results:

A statistically significant increase in micronuclei (MN) frequency was observed in Rh-positive individuals (196 ± 18.23) compared to Rh-negative individuals (169 ± 17.11) post-irradiation (p<0.001).

Conclusions:

The Rh factor shows potential as a predictive marker for individual radiosensitivity to ionizing radiation.
Further research is warranted to validate the Rh factor's role in predicting radiosensitivity.