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Related Experiment Video

Updated: Mar 13, 2026

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
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Expanded Dengue.

D B Kadam1, Sonali Salvi2, Ajay Chandanwale3

  • 1Professor & Head.

The Journal of the Association of Physicians of India
|October 21, 2016
PubMed
Summary
This summary is machine-generated.

Expanded dengue encompasses atypical presentations beyond severe forms. Recognizing these diverse, multisystemic manifestations is crucial for early diagnosis, especially during epidemics, to avoid unnecessary investigations.

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Area of Science:

  • Tropical Medicine
  • Infectious Diseases
  • Virology

Background:

  • Dengue virus causes a spectrum of illness, including severe forms like dengue shock syndrome and dengue hemorrhagic fever.
  • The World Health Organization (WHO) introduced the concept of 'expanded dengue' to include atypical presentations.
  • Dengue can mimic other mosquito-borne diseases (Malaria, Chikungunya, Zika) and is often not recognized as a cause of neurological conditions like encephalitis or Guillain-Barré syndrome.

Purpose of the Study:

  • To highlight the diverse and atypical clinical manifestations of dengue fever.
  • To emphasize the importance of considering dengue in differential diagnoses, especially during epidemics.
  • To underscore how understanding 'expanded dengue' aids in early and accurate diagnosis.

Main Methods:

  • Review of clinical presentations of dengue cases.
  • Analysis of atypical and multisystemic manifestations reported in literature and clinical practice.
  • Comparison with WHO case definitions for dengue fever.

Main Results:

  • Dengue presents with a wide array of atypical, multisystemic symptoms.
  • Neurological presentations such as encephalitis and seizures can be caused by dengue.
  • Dengue mimics other febrile illnesses, complicating diagnosis during co-existing epidemics.

Conclusions:

  • Atypical dengue presentations require a high index of suspicion for timely diagnosis.
  • Knowledge of expanded dengue syndrome is vital for clinicians managing febrile illnesses.
  • Early diagnosis of dengue, particularly during outbreaks, prevents extensive and often unnecessary investigations.