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Updated: Mar 13, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
Published on: April 16, 2012
Ontogeny of Tumor-associated CD4+CD25+Foxp3+ T-regulatory Cells
Qingsheng Li1, Nejat K Egilmez1
1a Department of Microbiology and Immunology , School of Medicine, University of Louisville , Louisville , KY , USA.
Abstract:
The critical contribution of CD4+CD25+Foxp3+ T-regulatory cells (Treg) to immune suppression in the tumor microenvironment is well-established. Whereas the mechanisms that drive the generation and accumulation of Treg in tumors have been an active area of study, the information on their origin and population dynamics remains limited. In this review, we discuss the ontogeny of tumor-associated Treg in light of the recently identified lineage markers.
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