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Updated: Mar 13, 2026
Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
[Clinicopathologic Features and Prognostic Implications in 72 Cases with Lung Adenosquamous Carcinoma]
Xi Wu1, Junling Li2, Shulan Chen3
1General Department, National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Background:
Adenosquamous carcinoma (ASC) is a rare subtype of lung cancer, it is mixed glandular and squamous cell carcinoma with a more aggressive behavior and poor prognosis than the other histologic subtypes. The aim of the study was to explore the clinicopathological characteristics and prognostic factors of ASC.
Methods:
A total of 72 patients were enrolled. We investigated clinicalpathological features and prognostic factors retrospectively.
Results:
The overall 72 ASC patients' median age was 34.7 months, 5-year survival rate was 14.9%. The influence of tumor size, M stage, and N stage, gene mutation and surgery on the prognosis of patients show statistical significance.
Conclusions:
ASC is characterized by both histologic aggressiveness and adverse prognosis. We suggest the comprehensive therapy based on surgery, and given small molecule tyrosine kinase inhibitors (TKIs) treatment may prolong patients' overall survival.
