[The clinical and histopathological analysis of 2 053 cases of conjunctival neoplasms]

Objective: We aimed to identify and describe the clinical and histopathologic characteristics of conjunctival neoplasms. Methods: Retrospective case series study. We collected and analyzed the clinical and histopathologic data of the conjunctival neoplastic specimens including the age, gender, and histopathologic diagnosis of all patients obtained from Beijing Tongren Eye Center between October 2003 and October 2015. All the pathology diagnosis results were divided into two categories which were benign and malignant tumors, according to Shields histopathological classification methods and the pathology diagnosis results in our department. All cases were divided into four groups as 0-17 years old, 18-39 years old, 40-59 years old, aged 60 and above. The chi-square test was used for statistical analysis. Results: Of the 2 053 cases, 1 025 were males and 1 028 were females (male∶female=1∶1). 1660 cases (80.9%) were benign and 393 cases(19.1%) were premalignant or malignant. The average age at diagnosis was 30.5 years for benign lesions and 53.3 years for premalignant and malignant lesions, which was significant different (P<0.01). The most common benign lesions were nevus, cysts, dermoids and dermolipomas, inflammatory granulomas and squamous cell papillomas. The most common premalignant and malignant tumors were CIN, melanomas, lymphomas and squamous cell carcinoma. The constitution of males and females of cysts, squamous cell papillomas, primary acquired melanosis, CIN and lymphomas were significant different (P<0.01). Moreover, the most common benign and malignant neoplasm were dermoids and dermolipomas, melanomas respectively in group under 18 years old. And nevus and lymphomas were the most common benign and malignant tumors respectively in patients between 18 and 39 years old. While cysts and CIN were the most common benign and malignant tumors respectively in cases over 40 years old. Conclusions: The majority of tumors of the conjunctiva were benign, with the young people being most. The premalignant and malignant tumors were more frequent in the elderly. Nevus and CIN were the most common benign and malignant tumors, respectively.(Chin J Ophthalmol, 2016, 52: 738-744).