[Clinical and pathological features and surgical treatment of eyelid/conjunctival amyloidosis]

Objective: To study the clinical and pathological features and surgical outcome of eyelid/conjunctival amyloidosis. Methods: It was a retrospective case series study. The clinical and pathological records of 11 patients who were diagnosed as eyelid/conjunctival amyloidosis and had surgical treatment between February 2007 and October 2015 at Beijing Tongren Hospital were analyzed. Routine pathological examinations and Congo red staining were performed. All of the 11 patients received surgical treatment. Seven patients with ptosis underwent surgical excision and ptosis repair. One patient with lower eyelid mass underwent surgical excision and reconstruction of the lower eyelid. One patient with upper eyelid mass underwent surgical excision. Two patients with conjunctival mass underwent surgical excision. Results: In the 11 patients, 6 were male and 5 were female. The mean age was 31 years old, median age was 21 years old, and the range of age was13-59 years old. Eight cases presented as eyelid thickening and nodular growth of the conjunctiva, and 7 of them had ptosis. One case presented as tumor of the upper lid. Two cases presented as conjunctival masses at the semilunar fold. None of the patients were found to have systemic involvement. All of the 11 cases received surgical treatment including excision of the lesions and correction of ptosis when necessary. Pathological examinations confirmed the diagnosis of amyloidosis. Follow up time was 1-9 years. Nine cases were stable, 1 case had progression in the conjunctival lesion and 1 case was lost to follow up. Conclusions: Eyelid/conjunctival amyloidosis usually present as mass or diffuse thickening of the eyelid/conjunctiva. The outcome of surgical treatment was satisfying.(Chin J Ophthalmol, 2016, 52: 775-779).