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CD127 Expression in Naive and Memory T Cells in HIV Patients Who Have Undergone Long-Term HAART
Wenfang Xu1, Jie Li2, Yong Wu3
1Clinical Laboratory, Shao Xing Municipal Hospital, Shaoxing, China.
Insights
Cluster of differentiation (CD)127 expression on T cells is reduced in individuals with human immunodeficiency virus type 1 (HIV-1). Lower CD127 levels correlate with impaired CD4+ T-cell recovery and reduced naive T-cell subsets.
Area of Science:
- Immunology
- Virology
- Cell Biology
Background:
- Human immunodeficiency virus type 1 (HIV-1) infection impacts T-cell populations.
- Understanding T-cell dynamics is crucial for managing HIV-1 disease progression.
Purpose of the Study:
- To investigate cluster of differentiation (CD)127 expression in T cells of HIV-1 patients.
- To determine the relationship between CD127 expression and HIV-1 disease progression.
Main Methods:
- 139 HIV-1 patients were categorized based on CD4+ T-cell counts after highly active antiretroviral therapy (HAART).
- Flow cytometry was used to quantify T-cell subsets, including naive (CD45RA+) and memory (CD45RO+) cells, and CD127 expression.
Main Results:
- Patients with good CD4+ T-cell recovery exhibited higher counts of CD4+CD45RO+, CD4+CD45RA+, CD4+CD45RO+CD127+, and CD4+CD45RA+CD127+ T cells.
- Reduced percentages of CD45RA+ and CD127+ T cells were observed in patients with poor and general recovery.
- CD127 expression positively correlated with CD4+ T-cell counts and CD45RA+ subset percentages.
Conclusions:
- CD127 expression is diminished in T cells of HIV-1 patients.
- Decreased CD127 expression is associated with impaired CD4+ T-cell count recovery and reduced naive T-cell subsets in HIV-1 infection.
Objective:
To evaluate cluster of differentiation (CD)127 expression in T cells of patients with HIV-1 and the relationship of CD127 expression with disease progression.
Methods:
We divided 139 patients infected with human immunodeficiency virus type 1 (HIV-1) who had undergone highly active antiretroviral therapy (HAART) into 3 groups: patients with poor recovery (CD4+T < 350/μ;L, patients with general recovery (CD4+T = 350 - ∼600/μL) and patients with good recovery (CD4+T > 600/μL). Counts and percentages of naïve (CD45RA+) and memory (CD45RO+) T cells and CD127 expression were determined using flow cytometry.
Results:
CD4+CD45RO+, CD4+CD45RA+, CD4+ CD45RO+ CD127+, and CD4+CD45RA+CD127+T-cell counts in patients with good recovery were higher than in patients with poor recovery and those with general recovery patients (P <.05). Percentages of CD45RO+ were increased, and percentages of CD45RA+ and CD127 in T cells were decreased in patients with poor and general recovery (P <.05). CD127 values were positively correlated with CD4+T-cell counts and percentages of CD45RA+ subsets (P <.05).
Conclusion:
CD127 expression in T cells is decreased in patients with HIV-1 and is related to recovery of CD4+T-cell counts and to naïve subsets.
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