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Extraosseous Ewing's sarcoma. A study of 42 cases
N P Rud1, H M Reiman, D J Pritchard
1Section of Surgical Pathology, Mayo Clinic, Rochester, Minnesota 55905.
Cancer
|October 1, 1989
Summary
Extraosseous Ewing's sarcoma (EES) is a rare soft tissue cancer. Wide surgical resection with negative margins and adjuvant radiation therapy improved survival rates for EES patients.
Area of Science:
- Oncology
- Pathology
Background:
- Extraosseous Ewing's sarcoma (EES) is a rare malignant neoplasm.
- This study focuses on soft tissue EES without primary bone involvement.
Purpose of the Study:
- To retrospectively analyze the clinical behavior and management of EES.
- To identify factors influencing survival in EES patients.
Main Methods:
- Retrospective review of 42 patients with soft tissue EES diagnosed between 1935 and 1985.
- Analysis of clinical data, treatment modalities, and patient outcomes.
Main Results:
- Metastases occurred in 30 patients, commonly to lungs or bone.
- Local recurrence was observed in 46% of patients.
- Five-year survival was 38.5%, with improved outcomes for patients treated since 1970 (48% vs. 28%).
Conclusions:
- Wide surgical resection with negative margins and adjuvant radiation therapy are associated with improved survival.
- Pelvic tumors, incomplete resections, and metastatic disease negatively impact survival.
- Advances in management since 1970 have led to better prognoses for EES.