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Updated: Mar 13, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Calcified synovial metastasis in the knee from renal cell carcinoma: a case report
Michael McConnell1, Rajendra Kumar2, Behrang Amini1
1Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1515- Holcombe Blvd, Unit 1475, Houston, TX, 77030, USA.
Abstract:
We present the case of an 83-year-old man who had painful swelling of right knee for 6 months. Radiographs showed a large intra-articular soft-tissue mass with small calcifications, whereas MRI detected a multilobulated intra-articular tumor with bone erosions at the distal femur. Histopathology of ultrasound-guided biopsy specimen of the synovial mass revealed it to be a poorly differentiated metastatic carcinoma. Abdominal computed tomography with intravenous contrast medium administration found a heterogeneously enhancing large right renal mass with calcifications, which was shown to be a renal cell carcinoma on histopathology. No metastases were found elsewhere. To our knowledge, this is the first reported case with MRI findings of a calcified intra-articular synovial metastasis from renal cell carcinoma.

