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Encapsulation of the HDACi Ex527 into Liposomes and Polymer-Based Particles
1Institute for Molecular Medicine, Cancer and Inflammation Research, University of Southern Denmark, J.B. Winsløws Vej 25, Odense C, 5000, Denmark.
Methods in Molecular Biology (Clifton, N.J.)
|October 21, 2016
Abstract:
Incorporation of drugs into particles can improve their therapeutic effectiveness. Solubility, half-life time, targeting, and the release of the drug can be modified by the encapsulation into a particle. Histone deacetylase inhibitors have a great potential to be used as therapeutics for many different diseases. In this chapter, we describe the inclusion of the low molar mass HDACi Ex527 into polymer-based particles and liposomes.

