Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

3.6K
Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing forest availability for wood supply in Europe.

Forest policy and economics·2020
Same author

Modification of human pericardium by chemical crosslinking.

Physiological research·2019
Same author

SPR biosensor for quantification of fetuin-A as a promising multibiomarker.

Physiological research·2018
Same author

New therapeutic strategy for chronifying back pain. The multimodal, interdisciplinary therapeutic program.

Der Orthopade·2017
Same author

Protein interactions with quaternized chitosan/heparin multilayers.

Physiological research·2016
Same author

[Not Available].

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2016
Same journal

Effects of THC, CBD, and Their Combination on EEG Dynamics in Rats.

Physiological research·2026
Same journal

Prophylactic Effect of Echinacoside on PIPN by Inhibiting Spinal Neuroinflammation and Exerting Neuroprotective Effects.

Physiological research·2026
Same journal

Comparison of Motor Learning Abilities Using Balance Training in Young and Senior Women.

Physiological research·2026
Same journal

The Role of NAT10-Mediated ac4C Modification in Osteoblast Function and Bone Formation: Insights from Integrative Bioinformatics and Experimental Validation.

Physiological research·2026
Same journal

Challenges and Solutions in Low-Biomass Respiratory Microbiome Profiling: A Workflow for Bronchoalveolar Lavage Fluid Sequencing in Guinea Pigs.

Physiological research·2026
Same journal

Sodium Selenite Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension by Upregulating GPX3 and Ameliorating Vascular Remodeling.

Physiological research·2026
See all related articles

Related Experiment Video

Updated: Mar 13, 2026

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion
07:14

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Published on: May 10, 2020

4.4K

Fibrin nanostructures for biomedical applications.

Z Riedelová-Reicheltová1, E Brynda, T Riedel

  • 1Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Prague, Czech Republic. riedel@imc.cas.cz.

Physiological Research
|October 21, 2016
PubMed
Summary
This summary is machine-generated.

Researchers developed novel fibrin nanostructures for tissue engineering. This technique precisely controls fibrin morphology on surfaces, enhancing biomaterial integration and therapeutic outcomes for various biomedical applications.

More Related Videos

Production of Nanofibrillar Patterned Collagen for Tissue Engineering
07:34

Production of Nanofibrillar Patterned Collagen for Tissue Engineering

Published on: September 20, 2024

1.1K
ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly
16:33

ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly

Published on: April 17, 2014

13.0K

Related Experiment Videos

Last Updated: Mar 13, 2026

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion
07:14

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Published on: May 10, 2020

4.4K
Production of Nanofibrillar Patterned Collagen for Tissue Engineering
07:34

Production of Nanofibrillar Patterned Collagen for Tissue Engineering

Published on: September 20, 2024

1.1K
ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly
16:33

ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly

Published on: April 17, 2014

13.0K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Fibrin is a crucial biopolymer widely utilized in tissue engineering applications.
  • Current methods for fibrin-based biomaterials can lead to bulk gel formation, limiting precise structural control.
  • Developing methods for controlled fibrin nanostructure formation is essential for advanced biomedical applications.

Purpose of the Study:

  • To present a novel technique for preparing surface-attached fibrin nanostructures.
  • To investigate the influence of polymerization time, antithrombin III, and heparin concentrations on nanostructure morphology.
  • To confirm the binding capacity of fibrin nanostructures for various bioactive molecules.

Main Methods:

  • Utilized a technique based on the catalytic effect of fibrin-bound thrombin for fibrin polymerization.
  • Controlled fibrin nanostructure formation on surfaces, avoiding bulk gelation.
  • Explored variations in polymerization time and concentrations of antithrombin III and heparin.
  • Confirmed binding of fibronectin, laminin, collagen, VEGF, bFGF, and heparin.

Main Results:

  • Successfully prepared surface-attached fibrin nanostructures with precisely regulated morphology.
  • Demonstrated that polymerization time and concentrations of antithrombin III and heparin influence nanostructure morphology.
  • Confirmed the successful binding of multiple bioactive molecules to the fibrin nanostructures.
  • Showcased the potential for surface modification of various artificial biomaterials.

Conclusions:

  • The presented technique offers precise control over fibrin nanostructure formation for surface-attached applications.
  • Fibrin nanostructures exhibit versatile binding capabilities for essential bioactive molecules.
  • These nanostructures hold significant potential for enhancing the performance of biomaterials in diverse biomedical fields.