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SPR biosensor for quantification of fetuin-A as a promising multibiomarker.

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This study introduces a novel biosensor for early cancer detection using fetuin-A as a biomarker. The advanced polymer brush technology ensures high sensitivity and accuracy in real blood samples, improving patient outcomes.

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Area of Science:

  • Biomedical Engineering and Materials Science
  • Nanotechnology and Biosensing

Background:

  • Early diagnosis of malignant diseases is critical for patient survival and quality of life, yet current methods often detect cancer in late stages.
  • Existing diagnostic tools face challenges with sensitivity and specificity, necessitating advanced biomarker detection technologies.

Purpose of the Study:

  • To develop and present a novel biosensor platform for the sensitive detection of fetuin-A, a potential multibiomarker for early cancer diagnosis.
  • To leverage advanced polymer brush technology for creating a highly effective, non-fouling biosurface for use in clinical diagnostics.

Main Methods:

  • Fabrication of a biosensing platform using surface-initiated atom transfer radical polymerization of N-(2-hydroxypropyl)methacrylamide (HPMA) and carboxybetaine methacrylamide (CBMAA) copolymer.
  • Characterization of the poly(HPMA-co-CBMAA) copolymer for its antifouling and antithrombogenic properties in biological media like blood plasma.
  • Functionalization of the polymer brush with biorecognition elements and integration into a plasmonic biosensor for fetuin-A detection in clinical samples.

Main Results:

  • The poly(HPMA-co-CBMAA) copolymer demonstrated excellent non-fouling and antithrombogenic properties, preventing adhesion of blood components.
  • The functionalized polymer brush maintained high resistance to biofouling while preserving binding capacity, tunable by adjusting the monomer ratio.
  • The developed plasmonic biosensor successfully detected fetuin-A in real clinical blood plasma samples, showcasing its diagnostic potential.

Conclusions:

  • The novel polymer brush-based biosensor offers a sensitive and reliable method for detecting biomarkers like fetuin-A in complex biological samples.
  • This labelfree affinity biosensor technology holds promise for advancing early cancer diagnostics and enabling point-of-care analysis.
  • The antifouling properties are key to the biosensor's performance in real clinical settings, paving the way for improved diagnostic strategies.