Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiovascular changes in chronically adrenalectomized conscious rats.

R D Stith1, M Bhaskar, Y S Reddy

  • 1Department of Physiology and Biophysics, University of Oklahoma Health Sciences Center, Oklahoma City 73190.

Circulatory Shock
|August 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cross-sectional survey of the incidence, mortality and socioeconomic burden of snakebite envenoming in India.

Nature communications·2025
Same author

Emerging applications of sustainable modified CdO/Ag-CdO NPs for electrochemical sensitive and selective detection of mercury (Hg<sup>+</sup>) heavy metal.

Scientific reports·2025
Same author

Development of a sustainable and disposable modified Bi-CdFe<sub>2</sub>O<sub>4</sub> electrode for electrochemical sensing of lead (II) and Acetaminophen drug molecule.

Scientific reports·2024
Same author

Controlled drug release for inflammatory bowel disease (IBD).

Bioinformation·2020
Same author

Adolescent alcohol exposure produces sex differences in negative affect-like behavior and group I mGluR BNST plasticity.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2020
Same author

<i>Eugenia jambolana</i> extract reduces the systemic exposure of Sitagliptin and improves conditions associated with diabetes: A pharmacokinetic and a pharmacodynamic herb-drug interaction study.

Journal of traditional and complementary medicine·2019

Chronic adrenalectomy (ADX) in rats leads to hypotension and reduced cardiac output, with full cardiovascular effects developing over weeks. This study highlights the importance of conscious models for understanding ADX impacts.

Area of Science:

  • Cardiovascular Physiology
  • Endocrinology

Background:

  • Adrenalectomy (ADX) significantly impacts cardiovascular function.
  • Understanding the long-term cardiovascular consequences of ADX requires careful experimental design.

Purpose of the Study:

  • To investigate the chronic cardiovascular effects of adrenalectomy in conscious rats.
  • To assess the impact of adrenalectomy on cardiovascular responses to epinephrine.
  • To evaluate the influence of anesthesia on cardiovascular measurements in adrenalectomized rats.

Main Methods:

  • Measurements of mean arterial blood pressure (MABP), heart rate (HR), stroke volume index (SVI), cardiac index (CI), systemic vascular resistance index (SVRI), and central venous pressure (CVP) in sham-operated (SO) and adrenalectomized (ADX) rats.
  • Cardiovascular responses to epinephrine infusion were assessed in conscious rats.

Related Experiment Videos

  • Comparisons were made between conscious and anesthetized states.

    • Main Results:

    • Adrenalectomized rats exhibited hypotension, tachycardia, and diminished SVI and CI by 3 weeks post-surgery.
    • Heart rate decreased and SVRI increased between 3 and 6 weeks after ADX.
    • Anesthesia masked the cardiovascular changes observed in conscious ADX rats.
    • Epinephrine responsiveness was unaltered, but peak MABP response was reduced in ADX rats, indicating impaired blood pressure regulation.
    • No significant electrolyte or hematocrit differences explained these effects.

    Conclusions:

    • Chronic adrenalectomy impairs cardiovascular function, leading to hypotension and reduced cardiac output over several weeks.
    • Conscious rat models are crucial for accurately studying the cardiovascular effects of adrenalectomy.
    • Enflurane anesthesia has a significant cardio-depressant effect that can obscure findings.