Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Corticosteroid-binding globulin in depression.

A Leake1, H W Griffiths, J A Pascual

  • 1MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne, UK.

Clinical Endocrinology
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A study of wrist-worn activity measurement as a potential real-world biomarker for late-life depression.

Psychological medicine·2016
Same author

Altered hippocampal function in major depression despite intact structure and resting perfusion.

Psychological medicine·2016
Same author

The interrelationship between attentional and executive deficits in major depressive disorder.

Acta psychiatrica Scandinavica·2016
Same author

Evidence-based guidelines for treating bipolar disorder: Revised third edition recommendations from the British Association for Psychopharmacology.

Journal of psychopharmacology (Oxford, England)·2016
Same author

Topic: Educations from the Specialistic Society and from the University.

Hernia : the journal of hernias and abdominal wall surgery·2015
Same author

Presence of pharmaceuticals and heavy metals in the waters of a Mediterranean coastal wetland: Potential interactions and the influence of the environment.

The Science of the total environment·2015
Same journal

Supraphysiological Glucocorticoid Doses and Pitfalls of Annual Biomarker Monitoring in Adults With CAH.

Clinical endocrinology·2026
Same journal

Subacute Thyroiditis in Denmark: A Nationwide Study of 1763 Cases.

Clinical endocrinology·2026
Same journal

Pubertal Dynamics of Sertoli and Leydig Cell Dysfunction in Klinefelter Syndrome.

Clinical endocrinology·2026
Same journal

Regarding Non-Classical Presentations of Rare Hereditary Hypoparathyroidism: A Case Series of CASR, GNA11, and GATA3 Mutations in Parathyroidology.

Clinical endocrinology·2026
Same journal

Dual Metabolic Burden of Polyendocrine Metabolic Ovarian Syndrome (PMOS) and Gestational Diabetes in Pregnancy: Impact on Neonatal Anthropometry: Insights From the Born in Bradford Cohort.

Clinical endocrinology·2026
Same journal

Preoperative CALLY Index for Identifying Atypical Parathyroid Tumors.

Clinical endocrinology·2026
See all related articles

Depressed patients show higher levels of free and total cortisol. Corticosteroid-binding globulin (CBG) levels and cortisol binding were similar between depressed individuals and controls, indicating cortisol dysregulation in depression.

Area of Science:

  • Endocrinology
  • Neuroscience
  • Psychiatry

Background:

  • Depression is associated with significant neuroendocrine alterations.
  • The hypothalamic-pituitary-adrenal (HPA) axis is frequently implicated in mood disorders.
  • Cortisol and its binding globulin (CBG) are key components of the HPA axis.

Purpose of the Study:

  • To investigate the role of plasma free and total cortisol levels in depression.
  • To assess the binding capacity and affinity of corticosteroid-binding globulin (CBG) for cortisol in depressed patients.
  • To explore potential correlations between cortisol levels, CBG, and depression subtypes.

Main Methods:

  • Plasma samples were collected from 15 drug-free depressed patients and 15 matched controls.
  • Blood draws were performed at 0900, 2300, and 1600 after dexamethasone administration.

Related Experiment Videos

  • Measurements included plasma free and total cortisol, and corticosteroid-binding globulin (CBG).

    • Main Results:

    • Depressed patients exhibited elevated concentrations of both free and total cortisol across all time points.
    • Plasma CBG binding capacity and affinity for cortisol were comparable between depressed patients and controls.
    • No significant differences in CBG measures were observed when stratifying depressed subjects by age or dexamethasone suppression test (DST) results.

    Conclusions:

    • Elevated free and total cortisol levels are present in drug-free depressed patients.
    • Corticosteroid-binding globulin (CBG) function appears unaltered in depression.
    • Findings suggest a dysregulation in cortisol secretion or metabolism rather than altered CBG binding in depression.