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Published on: March 19, 2018
Effect of Platelet-Rich Fibrin on Peripheral Nerve Regeneration
Fatma Şenses1, Mustafa E Önder, Ismail D Koçyiğit
1*Atasehir ADSM, Barbaros Mah, Istanbul†Department of OMFS, Faculty of Dentistry, Kirikkale University‡Department of Pathology, Faculty of Veterinary, University of Kirikkale, Kirikkale||Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Yildirim Beyazit, Ankara¶Adil Mah. Polonez Cad. Sinpas Liva Turkuaz, Istanbul, Turkey.
Purpose:
This study aimed to evaluate the effect of platelet-rich fibrin (PRF) on peripheral nerve regeneration on the sciatic nerve of rats by using functional, histopathologic, and electrophysiologic analyses.
Materials And Methods:
Thirty female Wistar rats were divided randomly into 3 experimental groups. In group 1 (G1), which was the control group, the sciatic nerve was transected and sutured (n = 10). In group 2 (G2), the sciatic nerve was transected, sutured, and then covered with PRF as a membrane (n = 10). In group 3 (G3), the sciatic nerve was transected, sutured by leaving a 5-mm gap, and then covered by PRF as a nerve guide (n = 10). Functional, histopathologic, and electrophysiologic analyses were performed.
Results:
The total histopathologic semiquantitative score was significantly higher in G1 compared to G2 and G3 (P < 0.05). Myelin thickness and capillaries were significantly lower in G3 compared to G1 (P < 0.05). There was no statistically significant difference between the groups with regard to the functional and electrophysiologic results.
Conclusion:
The study results suggest that PRF decreases functional recovery in sciatic nerve injury. Further studies are required to determine the efficacy of PRF on peripheral nerve regeneration.
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