Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

1.2K
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
1.2K
Human Genetics01:28

Human Genetics

1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K
Neurochemical Transmission: Sites of Drug Action01:26

Neurochemical Transmission: Sites of Drug Action

3.8K
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mapping the neurovascular landscape in aging and dementia: cerebral small vessel disease markers in a multicenter Latin American cohort.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Activities of daily living and their neural correlates across the Alzheimer's disease continuum: Evidence from a Latin American cohort.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

The exposome of brain aging across 34 countries.

Nature medicine·2026
Same author

Clinical Manifestations.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Clinical Manifestations.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Alzheimer's Imaging Consortium.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Related Experiment Video

Updated: Mar 13, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

782

Multivariate synaptic and behavioral profiling reveals new developmental endophenotypes in the prefrontal cortex.

Jillian Iafrati1, Arnaud Malvache1, Cecilia Gonzalez Campo1

  • 1INSERM, 13009 Marseille, France; INMED UMR S 901, 13009 Marseille, France; Aix-Marseille Université, 13009 Marseille, France.

Scientific Reports
|October 22, 2016
PubMed
Summary
This summary is machine-generated.

Revisiting the endophenotype approach reveals distinct developmental stages in prefrontal cortex maturation. Pharmacological treatments may create new endophenotypes rather than restore wild-type traits in psychiatric disorders.

More Related Videos

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning
10:36

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

Published on: December 15, 2016

11.1K
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.9K

Related Experiment Videos

Last Updated: Mar 13, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

782
High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning
10:36

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

Published on: December 15, 2016

11.1K
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.9K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Psychiatry

Background:

  • Postnatal prefrontal cortex (PFC) maturation is critical for cognitive development and vulnerable to neuropsychiatric disorders.
  • Reelin, an extracellular matrix protein, influences neural plasticity and is implicated as a risk factor in psychiatric diseases.
  • Understanding the developmental trajectory of PFC endophenotypes is crucial for dissecting disease mechanisms.

Purpose of the Study:

  • To investigate the aggregate effect of the RELN risk allele on postnatal PFC development and function.
  • To delineate developmental endophenotypic sequences associated with reelin haploinsufficiency.
  • To explore therapeutic strategies for psychiatric disorders by understanding endophenotype modulation.

Main Methods:

  • Cross-sectional synaptic and behavioral analysis in reelin-haploinsufficient mice.
  • Multivariate analysis of bootstrapped datasets to identify phenotypic subgroups across maturational epochs.
  • Assessment of synaptic AMPA/NMDA receptor content, long-term potentiation, memory renewal, and NMDA-GluN2B synaptic content.

Main Results:

  • Distinct subgroups of phenotypic traits were identified specific to pre-weaning, juvenile, adolescent, and adult maturational epochs.
  • Synaptic receptor content dominated early stages, shifting to potentiation and memory during adolescence, and NMDA-GluN2B content in adulthood.
  • Pharmacological interventions induced novel endophenotypes, rather than restoring wild-type characteristics, in reelin-haploinsufficient mice.

Conclusions:

  • This study delineates novel developmental endophenotypic sequences in the PFC.
  • Findings suggest that therapeutic interventions may operate by generating new endophenotypes.
  • This provides a strategic framework for understanding molecular underpinnings of psychiatric disorders and designing targeted pharmacotherapies.