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Related Concept Videos

Ultraviolet and Visible (UV–Vis) Spectroscopy: Overview01:02

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Ultraviolet–visible (UV–visible or UV–Vis) spectroscopy is an analytical technique that investigates the interaction between matter and UV–Vis light within the electromagnetic spectrum. This method is widely used for its versatility, simplicity, and relatively quick data acquisition, making it valuable for both qualitative and quantitative analysis. When UV–Vis radiation passes through a material,  molecules absorb light depending on the energy required for...
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UV–Vis Spectrometers01:14

UV–Vis Spectrometers

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The absorbance of UV and visible (UV–visible) radiations is measured using a UV–visible spectrophotometer. Deuterium lamps, which emit UV radiation, and tungsten lamps, which produce radiation in the visible region, are used as light sources in UV–visible spectrophotometers. A monochromator or prism is used for diffraction grating, i.e., to split the incoming radiation into different wavelengths. A system of slits is used to focus the desired wavelength on the sample cell.
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In Vitro Drug Release Testing: Overview, Development and Validation01:10

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In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
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Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

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Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
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In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

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Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
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Applications of IR Spectroscopy: Overview01:11

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The non-destructive nature and ability to provide valuable chemical information make IR spectroscopy a versatile technique with broad applications in various scientific and industrial fields. IR spectroscopy is commonly used to identify and characterize organic and inorganic compounds. It provides information about the functional groups present in a molecule and the bonding between atoms. This helps in the structural elucidation of compounds during organic synthesis, pharmaceutical research,...
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UV-Vis Spectroscopic Characterization of Nanomaterials in Aqueous Media
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Application of UV Imaging in Formulation Development.

Yu Sun1, Jesper Østergaard2

  • 1Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen Ø, Denmark.

Pharmaceutical Research
|October 22, 2016
PubMed
Summary
This summary is machine-generated.

UV imaging offers real-time visualization of drug dissolution and release, aiding pharmaceutical development. This technique helps understand formulation performance by monitoring drug transport and structural changes.

Keywords:
UV imagingdiffusiondissolutiondrug releasesolid state

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Area of Science:

  • Pharmaceutical Sciences
  • Analytical Chemistry
  • Materials Science

Background:

  • Efficient drug delivery relies on dissolution, release, and transport, necessitating understanding of drug-excipient interactions.
  • Physicochemical properties of active compounds and excipients critically influence formulation performance.
  • Quality control in drug manufacturing requires a deep understanding of drug release mechanisms.

Purpose of the Study:

  • To review the applications of UV imaging in pharmaceutical development.
  • To highlight the role of UV imaging in characterizing drug dissolution and release.
  • To explore the relationship between structural properties and drug formulation performance.

Main Methods:

  • UV imaging for real-time visualization of drug dissolution and release.
  • Qualitative and quantitative characterization of solution-phase drug transport.
  • Monitoring of events like polymer swelling, precipitation, and phase transitions.

Main Results:

  • UV imaging provides non-intrusive, real-time insights into drug release dynamics.
  • The technique visualizes critical events influencing drug performance.
  • It facilitates mechanistic understanding for formulation development.

Conclusions:

  • UV imaging is a valuable tool for early and late-stage pharmaceutical development.
  • It enhances the understanding of structure-performance relationships in drug formulations.
  • Future advancements may expand its application in drug delivery research.