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Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
Published on: September 4, 2017
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RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA)
Ursula Oestreicher1, Daniel Samaga1, Elizabeth Ainsbury2
1a Bundesamt fuer Strahlenschutz , Department Radiation Protection and Health , Oberschleissheim , Germany.
International Journal of Radiation Biology
|October 22, 2016
Summary
Inter-laboratory exercises optimized the dicentric chromosome assay (DCA) for biodosimetry. Harmonization and training within the European Network of Biodosimetry (RENEB) improved radiation dose assessment accuracy.
Area of Science:
- Biomedical sciences
- Radiation biology
- Genetics
Background:
- The Realizing the European Network of Biodosimetry (RENEB) project aims to enhance European biodosimetry capabilities.
- Standardization of the dicentric chromosome assay (DCA) is crucial for accurate radiation dose assessment.
Purpose of the Study:
- To optimize the dicentric chromosome assay (DCA) through inter-laboratory exercises.
- To identify training and harmonization needs within the RENEB network.
Main Methods:
- Organized two quality-controlled inter-laboratory exercises.
- Included blood sample shipment, processing, and analysis of chromosome aberrations.
- Participants performed manual scoring of dicentric chromosomes for dose estimation.
Main Results:
- Successful blood sample shipment within the EU; delays occurred outside the EU.
- Dose estimations successfully classified blood samples into medically relevant groups.
- The second exercise showed improved accuracy in dose estimations, particularly at higher doses.
Conclusions:
- Network pooling of resources enhances rapid classification of individuals in medically relevant groups during radiological incidents.
- Harmonization processes and training activities significantly benefited the RENEB network's performance.
