Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials01:16

Clinical Trials

11.1K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
11.1K
Clinical Trials: Overview01:11

Clinical Trials: Overview

5.3K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.3K
Nurses' Legal Responsibilities I01:27

Nurses' Legal Responsibilities I

2.1K
In healthcare, informed consent is a crucial process that involves thoroughly communicating medical treatment options to patients, including benefits, risks, potential side effects, and alternatives. This process enables patients to make well-informed decisions about their care, ensuring they understand the implications of their choices before consenting to or refusing treatment.
The legal responsibilities of a nurse regarding informed consent include the following:
2.1K
Blinding01:11

Blinding

4.0K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
4.0K
Ethics in Research01:56

Ethics in Research

26.1K
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
26.1K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

519
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
519

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

User-Centered Development of the MyCare<sup>2</sup> Comprehensive Digital Support Platform for Caregivers of Individuals With Cancer.

JCO clinical cancer informatics·2026
Same author

Supporting Caregivers During Ambulatory Cancer Surgery: Feasibility and Acceptability of a Brief Mindfulness-Based Intervention to Reduce Anxiety.

Seminars in oncology nursing·2026
Same author

Mindfulness in the Moment: A Five-Minute Meditation to Reduce COVID-19 Vaccination-Related Anxiety in Patients With Cancer.

Clinical journal of oncology nursing·2026
Same author

Cytokine-Cytokine Receptor Interaction and Endocytosis are Common Pathways for Symptom Burden and Sickness Behavior Symptoms in Oncology Patients Undergoing Chemotherapy.

Cancer medicine·2025
Same author

Assessing Health-Related Values: Imperative for Person-Centered Care.

The American journal of nursing·2025
Same author

Advancing Global Cancer Symptom Science: Insights and Strategies From the Inaugural Cancer Symptom Science Expert Meeting.

Nursing research·2025
Same journal

Exploring Information Needs of Patients With Cancer and Family Caregivers: A Descriptive and Network Analysis of End-of-Life Inquiries.

Oncology nursing forum·2026
Same journal

Postoperative Physiologic Comfort Management for Patients With Hepatocellular Carcinoma Undergoing Hepatic Arterial Infusion Chemotherapy.

Oncology nursing forum·2026
Same journal

Exploring Racial Disparities in Uterine Cancer Survival: A 20-Year, Single-Site Analysis.

Oncology nursing forum·2026
Same journal

What I See as an Editor: The Reach of Nurse-Led Intervention Oncology Research.

Oncology nursing forum·2026
Same journal

Trends and Hot Spots in Cancer Family Resilience: A Bibliometric and Visualization Study.

Oncology nursing forum·2026
Same journal

Seven-Year Cognitive Trajectories in Older Adult Cancer Survivors: Findings From a National Cohort Study.

Oncology nursing forum·2026
See all related articles

Related Experiment Video

Updated: Mar 13, 2026

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.4K

Informed Consent: A Clinical Trials Perspective

Marilyn J Hammer1, Patricia Eckardt2, Margaret Barton-Burke3

  • 1College of Nursing, New York University in New York.

Oncology Nursing Forum
|October 22, 2016
PubMed
Summary
This summary is machine-generated.

Cancer clinical trials aim to extend survival. This article discusses patient participation, informed consent, and challenges like healthcare literacy, ensuring ethical research practices.

Keywords:
biology of cancerethicsgeneticsnursing research

More Related Videos

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.4K
E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

9.3K

Related Experiment Videos

Last Updated: Mar 13, 2026

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.4K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.4K
E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

9.3K

Area of Science:

  • Oncology
  • Clinical Research Ethics

Background:

  • Cancer research trials primarily focus on improving patient survival rates.
  • Evaluating efficacy, safety, and tolerability are crucial in clinical trial assessments.
  • Adherence to ethical principles, such as those in the Belmont Report, is paramount.

Purpose of the Study:

  • To discuss reasons for patient participation in cancer clinical trials.
  • To highlight challenges encountered by patients during clinical trial enrollment.
  • To emphasize the importance of informed consent in cancer research.

Main Methods:

  • Case study analysis of two patients in cancer clinical trials.
  • Discussion of factors influencing patient enrollment decisions.
  • Exploration of ethical considerations in clinical trial participation.

Main Results:

  • Patient participation in clinical trials is driven by various factors, including trust in healthcare providers.
  • Healthcare literacy and the complexity of choosing between trials present significant challenges.
  • Ensuring genuine patient understanding for informed consent is critical.

Conclusions:

  • Ethical considerations and patient understanding are vital for successful cancer clinical trials.
  • Addressing challenges like health literacy can improve patient engagement and trial outcomes.
  • The decision to participate in a clinical trial requires careful consideration of benefits and risks.