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Fluorescence based fiber optic and planar waveguide biosensors. A review
Elena Benito-Peña1, Mayra Granda Valdés2, Bettina Glahn-Martínez1
1Department of Analytical Chemistry, Faculty of Chemistry, Complutense University, 28040 Madrid, Spain.
Analytica Chimica Acta
|October 23, 2016
Summary
This review covers fluorescence-based optical biosensors using fiber optics and planar waveguides. It details their principles, applications in environmental analysis, food safety, and clinical diagnosis, highlighting their versatility.
Area of Science:
- Optoelectronics and Biosensing
- Interdisciplinary Research (Chemistry, Physics, Biology, Engineering, Material Science)
Background:
- Optical biosensors, particularly fiber optic and planar waveguide types, are increasingly used in environmental, food safety, and clinical diagnostics.
- Fluorescence is the preferred signal transducer due to its high selectivity, sensitivity, and versatility.
Purpose of the Study:
- To provide an overview of fluorescence-based fiber optic and planar waveguide biosensors.
- To review biological recognition elements, sensing schemes, and recent applications (last 10 years).
Main Methods:
- Focus on working principles and configurations of fluorescence-based optical biosensors.
- Review of literature on biological recognition elements and sensing schemes.
- Compilation of major and recent applications in diverse fields.
Main Results:
- Detailed examination of fluorescence as a transducer signal in optical biosensors.
- Comprehensive review of sensor designs, recognition strategies, and application scope.
- Identification of trends and advancements in the field over the past decade.
Conclusions:
- Fluorescence-based optical biosensors are versatile tools with broad applicability.
- The field necessitates interdisciplinary collaboration for continued innovation and development.
- Significant progress has been made in the last ten years, with promising future applications.
