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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
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Formation of the Platelet Plug01:22

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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Inflammation01:38

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Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

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Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
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Related Experiment Video

Updated: Mar 13, 2026

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
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Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

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Platelets and infection.

Carsten Deppermann1, Paul Kubes1

  • 1Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada.

Seminars in Immunology
|October 23, 2016
PubMed
Summary
This summary is machine-generated.

Platelets interact with bacteria through surface receptors and granule proteins, contributing to host defense in severe sepsis. This review details these platelet-bacteria interactions and their role in infection.

Keywords:
BacteriaBacterial toxinsKupffer cellPlateletPlatelet surface receptorsSepsis

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An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
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Last Updated: Mar 13, 2026

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Area of Science:

  • Immunology
  • Hematology
  • Microbiology

Background:

  • Platelets are crucial for hemostasis but also implicated in various pathophysiological conditions, including infection.
  • Severe sepsis is a life-threatening condition with significant public health impact.
  • Platelets possess surface receptors and granule contents that mediate interactions with bacteria.

Purpose of the Study:

  • To review current knowledge on platelet-bacteria interactions.
  • To highlight recent advancements in understanding the role of platelets in sepsis and infection.

Main Methods:

  • Review of existing literature on platelet function in infection.
  • Analysis of platelet-bacteria interactions via surface receptors (e.g., GPIb, TLRs) and plasma proteins (e.g., fibrinogen, vWF).
  • Examination of platelet granule contents and their antimicrobial functions.

Main Results:

  • Platelets engage in direct and indirect interactions with bacteria.
  • Bacterial toxins activate platelets, leading to aggregation.
  • Platelets contribute to the host's antibacterial response through immune modulation and direct lysis of microbes.
  • Platelets interact with other immune cells like Kupffer cells and neutrophils.

Conclusions:

  • Platelets play a multifaceted role in host defense against bacterial infections, particularly in severe sepsis.
  • Understanding platelet-bacteria interactions is crucial for developing novel therapeutic strategies against sepsis.