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Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Updated: Mar 13, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

Cell-based therapies for neonatal lung disease.

Megan O'Reilly¹, Bernard Thébaud^2,3

¹Department of Physiology and Women and Children's Health Research Institute, University of Alberta, Edmonton, AB, Canada, T6G 2E1.

Cell and Tissue Research

|October 23, 2016

Summary

Bronchopulmonary dysplasia (BPD) is a common lung complication in preterm infants. Cell-based therapies show promise for preventing and repairing lung damage in BPD, offering new treatment avenues.

Keywords:

Bronchopulmonary dysplasia Lung injury Mesenchymal stem cell Preterm Regeneration

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Area of Science:

Neonatal Medicine
Respiratory Medicine
Regenerative Medicine

Background:

Preterm birth affects 11% of global births, with survivors often developing bronchopulmonary dysplasia (BPD).
BPD is a chronic lung disease with lifelong respiratory health consequences for affected infants.
Current treatments for BPD are limited, highlighting the need for novel therapeutic strategies.

Purpose of the Study:

To review recent pre-clinical research on cell-based therapies for BPD.
To summarize early clinical trial findings for these novel treatments.
To explore the potential of stem cell research in managing BPD.

Main Methods:

Literature review of pre-clinical studies on cell therapies for BPD.
Analysis of early-phase clinical trial data for cell-based interventions.
Synthesis of current evidence on the efficacy and safety of these therapies.

Main Results:

Pre-clinical data suggest cell therapies can prevent or repair lung damage in models of BPD.
Early clinical trials indicate potential benefits, but further research is needed.
Stem cell approaches are emerging as promising strategies for BPD management.

Conclusions:

Cell-based therapies represent a promising frontier for treating bronchopulmonary dysplasia.
Translational research is crucial for advancing these therapies from pre-clinical to clinical settings.
Further investigation is required to establish the long-term efficacy and safety of cell therapies for BPD.