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Treating Alopecia Areata: Current Practices Versus New Directions.
Aditya K Gupta1,2, Jessie Carviel3, William Abramovits4,5,6
1Department of Medicine, University of Toronto School of Medicine, Toronto, ON, Canada. agupta@execulink.com.
American Journal of Clinical Dermatology
|October 23, 2016
Summary
Alopecia areata (AA) is an autoimmune condition causing hair loss. Current treatments have limited efficacy and high relapse rates, prompting research into innovative therapies like biologics and PRP.
Area of Science:
- Dermatology
- Immunology
- Autoimmune Diseases
Background:
- Alopecia areata (AA) is a non-scarring autoimmune disorder causing varied hair loss.
- Current treatments for AA, including corticosteroids and immunotherapy, show variable efficacy and high relapse rates, particularly in severe cases.
Purpose of the Study:
- To review current treatment options for alopecia areata.
- To explore emerging and innovative therapies for managing AA.
Main Methods:
- Review of existing literature on alopecia areata treatments.
- Discussion of novel therapeutic approaches based on recent mechanistic insights.
Main Results:
- Established treatments like corticosteroids, topical immunotherapy, minoxidil, and bimatoprost are commonly used but have limitations.
- Innovative therapies including biologics, laser treatments, and autologous platelet-rich plasma (PRP) show promising preliminary results.
Conclusions:
- There is a need for more effective and durable treatments for alopecia areata.
- Emerging therapies offer potential for improved management of AA, particularly in severe and chronic cases.

