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Updated: Feb 27, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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[Nested melanoma].

M-H Jegou1, P Huet2, I Penchet3

  • 1Cabinet de dermatologie, 8, rue Jules-Ferry, 33290 Blanquefort, France.

Annales De Dermatologie Et De Venereologie
|October 25, 2016
PubMed
Summary
This summary is machine-generated.

Nested melanoma, a distinct subtype of melanoma, presents unique clinical, dermatoscopic, and histopathological features. Early identification is crucial, as it can be mistaken for benign nevi, especially in older adults.

Keywords:
CGH-arrayCHG-arrayDermatoscopieDermatoscopyFISHGlobular patternHybridation génomique comparativeHybridation in situ en fluorescenceMélanome en thèquesMélanome à extension superficielleNested melanomaPatron globulaireSuperficial spreading melanoma

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Nested melanoma is a recently described entity, first reported in 2012.
  • It is characterized by specific clinical, dermatoscopic, and histopathological features.
  • This study aims to highlight criteria for this melanoma subtype.

Observation:

  • A 52-year-old male presented with a large, irregular, and discolored pigmented lesion on his chest.
  • Dermatoscopy revealed a chaotic pattern with a structureless black area, peripheral globules, and segmental radial lines.
  • Histopathology showed an asymmetric lesion with large junctional melanocytic nests, focal gathering, and cytological atypia.

Findings:

  • Nested melanoma is a distinct anatomoclinical variant of superficial spreading melanoma.
  • Clinically, lesions are typically large and found on sun-damaged skin, though not exclusive to the elderly.
  • Key dermatoscopic findings include a globular pattern, alongside features of superficial spreading melanoma.

Implications:

  • Histological diagnosis can be challenging, mimicking benign nevi due to the nested pattern.
  • Distinguishing features include large, atypical junctional nests, bridging, and lesion asymmetry.
  • Recognizing these specific criteria is vital for accurate diagnosis and management of nested melanoma.