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Eugenol and Its Role in Chronic Diseases
1School of Dentistry, Meikai University, 1-1 Keyakidai Sakado, Saitama, 350-0283, Japan. fujisawa33@nifty.com.
Advances in Experimental Medicine and Biology
|October 25, 2016
Summary
Eugenol, found in cloves, shows significant antioxidant and anti-inflammatory effects, potentially preventing chronic diseases. Further human studies are needed to explore its therapeutic use.
Area of Science:
- Phytochemistry
- Medicinal Chemistry
- Computational Chemistry
Background:
- Cloves contain eugenol and isoeugenol, with eugenol gaining attention for chronic disease prevention.
- Eugenol exhibits radical-scavenging and anti-inflammatory properties demonstrated in vitro and in vivo.
- Human therapeutic applications of eugenol require further investigation.
Purpose of the Study:
- To review and discuss the antioxidant, anti-proliferative, and anti-inflammatory activities of eugenol and related compounds.
- To correlate experimental antioxidant data with theoretical parameters.
- To explore the potential of eugenol in alleviating and preventing chronic diseases.
Main Methods:
- Literature review of recent studies on eugenol and its derivatives.
- Analysis of experimentally determined antioxidant activity (stoichiometric factor n, inhibition rate constant).
- Calculation of theoretical parameters (BDE, IP, electrophilicity ω) using density functional theory (DFT).
Main Results:
- Eugenol and its related compounds, particularly dimers, exhibit significant antioxidant and anti-inflammatory activities.
- High electrophilicity (ω) values were observed in dimers, correlating with potent activity.
- Eugenol possesses multiple intrinsic antioxidant mechanisms, including dimerization, recycling, and chelation.
Conclusions:
- Eugenol demonstrates multifaceted antioxidant and anti-inflammatory potential.
- Computational and experimental data support eugenol's role in modulating chronic diseases.
- Eugenol holds promise for the prevention and alleviation of chronic conditions, warranting further clinical research.
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