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Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
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Eugenol and Its Role in Chronic Diseases.

S Fujisawa1, Y Murakami2

  • 1School of Dentistry, Meikai University, 1-1 Keyakidai Sakado, Saitama, 350-0283, Japan. fujisawa33@nifty.com.

Advances in Experimental Medicine and Biology
|October 25, 2016
PubMed
Summary

Eugenol, found in cloves, shows significant antioxidant and anti-inflammatory effects, potentially preventing chronic diseases. Further human studies are needed to explore its therapeutic use.

Keywords:
Anti-inflammatory activityAntioxidant activityEugenolPreventing chronic diseasesTheoretical parameter

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Area of Science:

  • Phytochemistry
  • Medicinal Chemistry
  • Computational Chemistry

Background:

  • Cloves contain eugenol and isoeugenol, with eugenol gaining attention for chronic disease prevention.
  • Eugenol exhibits radical-scavenging and anti-inflammatory properties demonstrated in vitro and in vivo.
  • Human therapeutic applications of eugenol require further investigation.

Purpose of the Study:

  • To review and discuss the antioxidant, anti-proliferative, and anti-inflammatory activities of eugenol and related compounds.
  • To correlate experimental antioxidant data with theoretical parameters.
  • To explore the potential of eugenol in alleviating and preventing chronic diseases.

Main Methods:

  • Literature review of recent studies on eugenol and its derivatives.
  • Analysis of experimentally determined antioxidant activity (stoichiometric factor n, inhibition rate constant).
  • Calculation of theoretical parameters (BDE, IP, electrophilicity ω) using density functional theory (DFT).

Main Results:

  • Eugenol and its related compounds, particularly dimers, exhibit significant antioxidant and anti-inflammatory activities.
  • High electrophilicity (ω) values were observed in dimers, correlating with potent activity.
  • Eugenol possesses multiple intrinsic antioxidant mechanisms, including dimerization, recycling, and chelation.

Conclusions:

  • Eugenol demonstrates multifaceted antioxidant and anti-inflammatory potential.
  • Computational and experimental data support eugenol's role in modulating chronic diseases.
  • Eugenol holds promise for the prevention and alleviation of chronic conditions, warranting further clinical research.