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Related Concept Videos

Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
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Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy
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Controlling cell adhesion using layer-by-layer approaches for biomedical applications.

Shanshan Guo1, Xiaoying Zhu2, Xian Jun Loh3

  • 1NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Kent Ridge, Singapore 117576, Singapore.

Materials Science & Engineering. C, Materials for Biological Applications
|October 25, 2016
PubMed
Summary
This summary is machine-generated.

Controlling cell adhesion on synthetic materials is crucial for biomedical applications. Polyelectrolyte multilayer films, using the layer-by-layer method, offer tunable surface properties to promote or inhibit mammalian and bacterial cell adhesion.

Keywords:
Biomedical applicationCell adhesionLbL assemblyMammalian and bacterial cellsSurface modification

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Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Cell Biology

Background:

  • Controlling mammalian and bacterial cell adhesion at synthetic material interfaces is vital for biomedical applications like tissue engineering and biosensors.
  • Surface properties significantly influence cell adhesion, necessitating methods to functionalize materials.
  • Polymeric coatings are employed to modify surface physicochemical properties for mediating cell adhesion.

Purpose of the Study:

  • To review the use of the layer-by-layer (LbL) method for creating polyelectrolyte multilayer films.
  • To explore how LbL-modified surfaces can be engineered to either promote or inhibit mammalian and bacterial cell adhesion.
  • To discuss the development of multifunctional surfaces that selectively interact with specific cell types.

Main Methods:

  • Utilizing the layer-by-layer (LbL) assembly technique to construct polyelectrolyte multilayer films.
  • Modifying the physicochemical properties of material surfaces through LbL film deposition.
  • Investigating the impact of surface modifications on mammalian and bacterial cell adhesion.

Main Results:

  • LbL method enables precise control over surface properties for cell adhesion modulation.
  • Engineered films can be designed to either enhance or reduce cell attachment.
  • Emerging multifunctional surfaces show potential for selective cellular responses.

Conclusions:

  • The LbL approach is a powerful tool for tailoring surface properties to control cell adhesion in biomedical contexts.
  • Functionalized surfaces can be developed for promoting or inhibiting specific cell adhesion.
  • Future research focuses on creating smart, multifunctional surfaces for advanced biomedical applications.