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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer

Barbara Jung1, Jonas J Staudacher1, Daniel Beauchamp2

  • 1University of Illinois at Chicago, Chicago, Illinois.

Gastroenterology
|October 25, 2016
PubMed

Insights

Transforming growth factor-beta (TGF-β) signaling is crucial for cell functions but often disrupted in colorectal tumors. This review examines how altered TGF-β signaling drives colorectal cancer and explores therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Signaling

Background:

  • Transforming growth factor-beta (TGF-β) cytokines regulate critical cellular processes like proliferation and differentiation.
  • Disruptions in TGF-β family signaling pathways are frequently observed in a significant percentage of colorectal tumors.

Purpose of the Study:

  • To review the alterations in TGF-β family member signaling during colorectal cancer development.
  • To discuss models used to study these alterations.
  • To explore pathway interactions and potential therapeutic strategies targeting TGF-β signaling in colorectal cancer.

Main Methods:

  • Literature review of studies on TGF-β signaling in colorectal cancer.
  • Analysis of molecular mechanisms underlying TGF-β pathway dysregulation.
  • Examination of preclinical and clinical models.

Main Results:

  • TGF-β signaling is commonly inactivated or aberrantly activated in colorectal tumors, promoting tumor progression.
  • Specific mutations and pathway crosstalk contribute to colorectal cancer pathogenesis.
  • Various therapeutic strategies targeting TGF-β signaling are under investigation.

Conclusions:

  • Altered TGF-β signaling is a key driver in colorectal cancer development and progression.
  • Understanding these alterations is vital for developing effective targeted therapies.
  • Future research should focus on precise therapeutic interventions for TGF-β pathway dysregulation.
Keywords:
ActivinColon CancerTransforming Growth Factor β

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