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Surface modification of copolyether-urethane catheters with poly(ethylene oxide).
E Brinkman1, A Poot, T Beugeling
1Department of Chemical Technology, Twente University of Technology, Department of Chemical Technology, Twente University of Technology, Enschede, The Netherlands.
The International Journal of Artificial Organs
|June 1, 1989
Summary
Poly(ethylene oxide) modification of Pellethane 2363 80A catheters significantly improved blood compatibility by reducing platelet deposition five-fold. This surface enhancement did not impact coagulation activation.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Medical Device Engineering
Background:
- Pellethane 2363 80A is a polyurethane used in medical devices.
- Improving the hemocompatibility of biomaterials is crucial for reducing thrombotic events.
- Surface modification is a key strategy to enhance the biocompatibility of medical implants.
Purpose of the Study:
- To enhance the blood compatibility of Pellethane 2363 80A catheters.
- To evaluate the effect of poly(ethylene oxide) modification on catheter surface properties and hemocompatibility.
Main Methods:
- Pellethane 2363 80A catheters were surface-modified with poly(ethylene oxide).
- Contact angle measurements were used to assess surface wettability.
- In vitro blood compatibility tests were performed to evaluate platelet deposition and coagulation activation.
Main Results:
- Surface modification increased the wettability of Pellethane 2363 80A.
- Poly(ethylene oxide) modification led to a five-fold reduction in platelet deposition.
- The activation of coagulation remained unaffected by the surface modification.
Conclusions:
- Surface modification of Pellethane 2363 80A with poly(ethylene oxide) enhances blood compatibility.
- The improved hemocompatibility is primarily due to reduced platelet adhesion.
- This modification presents a promising strategy for developing safer polyurethane-based medical devices.