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Rhizoma Coptidis: A Potential Cardiovascular Protective Agent.

Hui-Li Tan1, Kok-Gan Chan2, Priyia Pusparajah3

  • 1Novel Bacteria and Drug Discovery Research Group, School of Pharmacy, Monash University MalaysiaBandar Sunway, Malaysia; Biomedical Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University MalaysiaBandar Sunway, Malaysia.

Frontiers in Pharmacology
|October 25, 2016
PubMed
Summary

Rhizoma coptidis (RC) shows significant cardioprotective effects against cardiovascular diseases (CVDs). Its bioactive compounds offer potential in managing CVD risk factors and providing myocardial protection.

Keywords:
Coptis chinensis FranchHuang Liancardiovascular diseasescoptis rootethnopharmacology

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Area of Science:

  • Pharmacology and Traditional Medicine
  • Cardiovascular Research
  • Herbal Medicine Efficacy

Background:

  • Cardiovascular diseases (CVDs) are a leading global cause of mortality.
  • Rhizoma coptidis (RC), or Huang Lian, is a traditional Chinese herb used for over 2000 years.
  • RC is commonly used in traditional medicine to address CVD risk factors like obesity, diabetes, and hyperlipidemia.

Approach:

  • This review summarizes scientific literature on the cardioprotective properties of Rhizoma coptidis.
  • Investigates the biological activities of RC and its bioactive compounds.
  • Examines evidence for RC's effects on major CVD risk factors and myocardial protection.

Key Points:

  • RC demonstrates anti-atherosclerotic, lipid-lowering, anti-obesity, and anti-hepatic steatosis effects.
  • RC provides myocardioprotective benefits, particularly against ischemia-reperfusion injury.
  • Bioactive compounds like berberine and coptisine in RC contribute to its cardioprotective actions through various pathways.

Conclusions:

  • Rhizoma coptidis exhibits significant potential in reducing CVD risks and mitigating CVD-related damage.
  • Scientific evidence supports the traditional use of RC for cardiovascular health.
  • RC represents a promising natural therapeutic agent for cardiovascular disease management.