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The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual,  the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter...
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Related Experiment Video

Updated: Mar 13, 2026

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
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Dolly and Alice.

Dan L Burk1

  • 1University of California, Irvine, School of Law, 401 East Peltason Drive, Irvine, CA 92617, USA.

Journal of Law and the Biosciences
|October 25, 2016
PubMed
Summary

The Alice standard for patentable subject matter may have altered the Roslin Institute

Area of Science:

  • Biotechnology Patent Law
  • Intellectual Property Rights

Background:

  • The Federal Circuit's decision in In re Roslin Institute denied patent claims for cloned mammals.
  • This decision preceded the Supreme Court's Alice Corp. v. CLS Bank International ruling on patentable subject matter.
  • The Alice decision established a new standard for determining patent eligibility.

Purpose of the Study:

  • To analyze how the Alice standard might have impacted the Roslin Institute decision.
  • To explore the application of the Alice two-part test to 'products of nature' in cloned mammals.
  • To highlight issues in biotechnology patent law concerning subject matter eligibility.

Main Methods:

  • Hindsight analysis of the Roslin Institute case using the Alice standard.
  • Application of the Alice two-part test to cloned mammals as 'products of nature'.
Keywords:
biotechnologycloningintellectual propertypatent eligibilitypatentssubject matter

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  • Juxtaposition of the Roslin (Dolly) and Alice cases to examine subject matter jurisprudence.
  • Main Results:

    • The Alice standard could potentially lead to a different outcome in the Roslin case.
    • The analysis reveals complexities in applying current subject matter jurisprudence to biotechnology.
    • The Supreme Court's approach has resurfaced dormant issues in biotechnology patent law.

    Conclusions:

    • The Alice decision's subject matter analysis presents challenges for patenting biotechnological innovations.
    • Further clarification is needed on applying patent eligibility standards to novel biological creations.
    • The intersection of 'products of nature' and patent law requires careful consideration in emerging fields like cloning.