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Dynamic Metabolism in Immune Response.

Mazen Al-Hommrani1, Paramita Chakraborty1, Shilpak Chatterjee1

  • 1Departments of Surgery, Microbiology & Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.

Journal of Immunology Research and Therapy
|October 25, 2016
PubMed
Summary

This review explores how cellular metabolism fuels immune responses. Understanding energy dynamics in T cells and other immune cells is crucial for fighting infection and cancer.

Area of Science:

  • Immunology and Cellular Metabolism

Background:

  • Cellular survival and function depend on nutrient and energy metabolism.
  • Immune responses against pathogens or cancer rely on lymphoid and myeloid cells.
  • T cells, a diverse group of immune cells, play a critical role in adaptive immunity.

Purpose of the Study:

  • To review the dynamic metabolic states within various immune cell subsets.
  • To highlight the role of cellular metabolism in mounting effective immune responses.
  • To understand metabolic differences between T cell subsets, natural killer cells, dendritic cells, macrophages, and myeloid-derived suppressor cells.

Main Methods:

  • This review synthesizes recent findings on immune cell metabolism.
  • It focuses on the operational state of metabolism within cellular compartments.

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  • The review examines how metabolic differences impact immune cell function.

    • Main Results:

    • Significant differences in energy metabolism exist among various immune cell subsets.
    • Metabolic reprogramming is essential for immune cells to effectively combat infections and cancer.
    • Understanding these metabolic dynamics is key to developing novel therapeutic strategies.

    Conclusions:

    • Cellular metabolism is a critical determinant of immune cell function and response.
    • Targeting metabolic pathways offers potential for treating immune-related diseases and cancer.
    • Further research into immune cell metabolism will advance our understanding of health and disease.