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Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice
Yi-Ju Hsu1, Wen-Ching Huang2, Chien-Chao Chiu3
1Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan. 1041302@ntsu.edu.tw.
Nutrients
|October 25, 2016
Summary
Capsaicin (CAP) supplementation in mice improved exercise performance and reduced fatigue. This suggests CAP may enhance physical stamina and aid recovery from exertion.
Area of Science:
- Nutritional Biochemistry
- Exercise Physiology
- Pharmacology
Background:
- Chili pepper contains capsaicin (CAP), a bioactive compound with known effects on mitochondrial function.
- Limited research exists on CAP's impact on physical fatigue and exercise performance.
- CAP is a widely consumed spice with potential health benefits.
Purpose of the Study:
- To investigate the anti-fatigue and ergogenic effects of capsaicin supplementation.
- To evaluate CAP's influence on physiological markers post-exercise.
Main Methods:
- Female ICR mice were administered varying doses of CAP (0, 205, 410, 1025 mg/kg/day) for 4 weeks.
- Exercise performance was assessed via forelimb grip strength and exhaustive swimming time.
- Serum markers (lactate, ammonia, glucose, BUN, CK) and hepatic glycogen were analyzed post-exercise.
Main Results:
- The highest CAP dose (CAP-5X) significantly increased grip strength and swimming time.
- CAP supplementation dose-dependently decreased serum lactate, ammonia, BUN, and CK levels.
- CAP increased serum glucose and hepatic glycogen content, indicating improved energy homeostasis.
Conclusions:
- Capsaicin supplementation demonstrates significant anti-fatigue properties and enhances exercise performance in mice.
- CAP may improve energy metabolism and reduce exercise-induced physiological stress.
- Results suggest CAP's potential for promoting health, improving physical performance, and alleviating fatigue.
