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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Allergic Reactions02:06

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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Allergic Reactions: Anaphylaxis01:30

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Asthma-III: Symptoms and Complications01:24

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Allergy in severe asthma.

S R Del Giacco1, A Bakirtas2, E Bel3

  • 1Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Allergy
|October 25, 2016
PubMed
Summary
This summary is machine-generated.

Allergy is a significant risk factor for asthma exacerbations and severe adult asthma, especially when interacting with viral infections. Fungal allergy also plays a key role in severe asthma cases.

Keywords:
aetiologyallergyasthmaatopyseverity

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Area of Science:

  • Allergy and Immunology
  • Respiratory Medicine
  • Clinical Medicine

Background:

  • Atopic sensitization is a known risk factor for asthma in children and adults.
  • The precise role of allergy in severe asthma remains under investigation.
  • Severe asthma is a heterogeneous condition requiring high-level GINA guideline treatment.

Purpose of the Study:

  • To examine the current evidence on the role of allergy in severe asthma.
  • To provide a position document on allergy's impact on severe asthma.
  • To clarify the relationship between allergy and asthma severity.

Main Methods:

  • Review of epidemiological studies on asthma exacerbations and hospital admissions.
  • Analysis of the association between childhood allergic asthma and adult severe asthma.
  • Evaluation of the impact of viral infections and fungal allergy on asthma severity.

Main Results:

  • Allergy is implicated in asthma exacerbations, emergency room visits, and hospital admissions.
  • Childhood allergic asthma is linked to severe adult asthma.
  • Interactions between viruses and allergies, along with fungal allergy, increase asthma exacerbation risk.

Conclusions:

  • Allergy plays a critical role in the development and exacerbation of severe asthma.
  • Understanding the interplay of allergens, infections, and environmental factors is crucial for managing severe asthma.
  • Further research is needed to fully elucidate the mechanisms driving allergy-mediated severe asthma.