Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

850
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
850

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seizure relapse in new onset epilepsy: It is not always drug resistance.

Epilepsia·2026
Same author

Interrupting the perception-action cycle reshapes serial dependence and sensory processing.

Brain research·2026
Same author

EEG microstates: from methodological foundations to clinical translation.

Trends in neurosciences·2026
Same author

Microstate Dynamics of Focused Attention Meditation.

Brain topography·2026
Same author

Advances in ocular motor and pupil biomarkers for neurological disorders.

Brain communications·2026
Same author

Disentangling Event-Related Potential and Oscillatory Sources using Time- and Frequency-Domain Source Imaging.

Clinical neurophysiology practice·2026

Related Experiment Video

Updated: Mar 13, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.9K

Directed Functional Brain Connectivity Based on EEG Source Imaging: Methodology and Application to Temporal Lobe

Ana Coito, Christoph M Michel, Pieter van Mierlo

    IEEE Transactions on Bio-Medical Engineering
    |October 25, 2016
    PubMed
    Summary

    This study introduces a method to analyze brain connectivity using high-density EEG, finding distinct connectivity patterns in temporal lobe epilepsy (TLE) patients. These findings may aid in discovering new biomarkers for epilepsy.

    More Related Videos

    Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
    12:09

    Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

    Published on: August 5, 2014

    18.6K
    Concurrent EEG and Functional MRI Recording and Integration Analysis for Dynamic Cortical Activity Imaging
    11:28

    Concurrent EEG and Functional MRI Recording and Integration Analysis for Dynamic Cortical Activity Imaging

    Published on: June 30, 2018

    12.4K

    Related Experiment Videos

    Last Updated: Mar 13, 2026

    A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
    08:23

    A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

    Published on: November 13, 2016

    11.9K
    Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
    12:09

    Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

    Published on: August 5, 2014

    18.6K
    Concurrent EEG and Functional MRI Recording and Integration Analysis for Dynamic Cortical Activity Imaging
    11:28

    Concurrent EEG and Functional MRI Recording and Integration Analysis for Dynamic Cortical Activity Imaging

    Published on: June 30, 2018

    12.4K

    Area of Science:

    • Neuroscience
    • Computational Neuroscience
    • Medical Imaging

    Background:

    • Functional brain connectivity is crucial for understanding brain function and dysfunction.
    • Temporal lobe epilepsy (TLE) involves alterations in brain network activity.
    • Investigating directed functional connectivity offers insights into neurological disorders.

    Purpose of the Study:

    • To present a methodological pipeline for directed functional connectivity analysis using high-density EEG source signals.
    • To address methodological challenges in estimating directed functional connectivity.
    • To compare directed functional connectivity between TLE patients and healthy controls.

    Main Methods:

    • EEG acquisition, preprocessing, and electrical-source imaging (ESI) with individual head models.
    • Gray matter parcellation, dipole orientation fixation, and spectral power computation.
    • Directed functional connectivity estimation using Granger-causal modeling.

    Main Results:

    • A threefold signal-to-noise ratio (SNR) increase was achieved by projecting dipoles to their predominant orientation.
    • Significant frequency-specific outflow differences were identified between TLE patients and controls.
    • These differences were observed in physiologically plausible brain regions.

    Conclusions:

    • Directed functional connectivity derived from ESI can enhance understanding of resting-state network alterations in focal epilepsy.
    • This approach may contribute to identifying novel biomarkers for TLE and similar disorders.