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Physiological Functions of NO-Sensitive Guanylyl Cyclase Isoforms.

Doris Koesling1, Evanthia Mergia, Michael Russwurm

  • 1Abteilung für Pharmakologie, Medizinische Fakultät, Ruhr-Universität Bochum, Universitätsstr. 150, 44780 Bochum, Germany.

Current Medicinal Chemistry
|October 26, 2016
PubMed
Summary

Two isoforms of nitric oxide-sensitive guanylyl cyclase (NO-GC1 and NO-GC2) are coexpressed in most tissues. In the central nervous system, NO-GC1 and NO-GC2 play distinct presynaptic and postsynaptic roles, respectively.

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