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Related Experiment Video

Updated: Mar 13, 2026

Fat Preference: A Novel Model of Eating Behavior in Rats
05:57

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Stevia preferences in Wistar rats.

Paula Núñez Martínez1, Juan Argüelles Luis, Carmen Perillán Méndez

  • 1Universidad de Oviedo.

Psicothema
|October 26, 2016
PubMed
Summary

Rats prefer stevia extract and rebaudioside A over water, with peak intake at specific concentrations. This research aids in selecting appropriate dosages for future stevia studies.

Area of Science:

  • Food science and nutrition
  • Natural sweeteners

Background:

  • Stevia rebaudiana is a key source of natural, high-potency sweeteners like rebaudioside A and stevioside.
  • These steviol glycosides share pharmacokinetic profiles, making studies on one relevant to the other.
  • Mammalian sweet intake demonstrates significant variability.

Purpose of the Study:

  • To investigate Wistar rat responses to various concentrations of stevia extract and pure rebaudioside A.
  • To compare preferences for stevia compounds against saccharin and water.
  • To evaluate responses to a commercial stevia product containing rebaudioside A and erythritol.

Main Methods:

  • Two-bottle preference tests were employed.
  • A range of sweetener concentrations were tested against saccharin and water.

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Main Results:

  • Wistar rats showed preference for stevia extract and rebaudioside A solutions over water across tested concentrations (0.001% to 0.3%).
  • Peak preference for stevia extract and rebaudioside A occurred at a 0.1% concentration.
  • Rats also preferred a mixture of rebaudioside A and erythritol over water, with peak preference at 2% concentration.

Conclusions:

  • This study offers novel insights into Wistar rat reactions to stevia compounds and commercial products like Truvia.
  • Findings can guide the selection of optimal dosages for subsequent behavioral and physiological research on stevia.