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AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
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A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction
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Kidney Function After the First Kidney Stone Event.

William E Haley1, Felicity T Enders2, Lisa E Vaughan2

  • 1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.

Mayo Clinic Proceedings
|November 8, 2016
PubMed
Summary
This summary is machine-generated.

Kidney function in first-time kidney stone formers returns to normal, but sustained higher cystatin C and proteinuria may increase long-term chronic kidney disease risk.

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Area of Science:

  • Nephrology
  • Urology
  • Biochemistry

Background:

  • Kidney stones are a common condition.
  • The long-term impact of kidney stones on kidney function is not fully understood.
  • Assessing kidney function post-stone event is crucial for patient management.

Purpose of the Study:

  • To investigate persistent changes in kidney function after a first symptomatic kidney stone event.
  • To compare kidney function between kidney stone formers and matched controls.

Main Methods:

  • Prospective study comparing incident symptomatic stone formers and controls.
  • Two study visits 90 days apart to assess kidney function (serum creatinine, cystatin C, urine protein, albuminuria).
  • Statistical analysis adjusted for clinical, blood, and urine risk factors.

Main Results:

  • Stone formers showed transiently elevated serum creatinine levels post-event, which resolved.
  • Sustained higher serum cystatin C and urine protein levels were observed in stone formers compared to controls.
  • Increased likelihood of albuminuria in stone formers at both study visits.

Conclusions:

  • While serum creatinine normalizes after a first kidney stone, persistent abnormalities in cystatin C and proteinuria indicate potential long-term kidney damage.
  • These findings suggest an increased risk of chronic kidney disease in individuals with a history of kidney stones.
  • Further monitoring of kidney function is recommended for stone formers.