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Dermatosparaxis in two Limousin calves.

Catherine I Carty1, Alison M Lee1, Nathan A E Wienandt2

  • 1School of Veterinary Medicine, Veterinary Sciences Centre, University College Dublin, Belfield, Dublin 4, Ireland.

Irish Veterinary Journal
|October 26, 2016
PubMed
Summary
This summary is machine-generated.

Dermatosparaxis, a severe skin fragility disorder, was diagnosed in two Limousin calves. This is the first report in this breed, highlighting the need for further genetic investigation due to the lethal phenotype.

Keywords:
BovineDermatosparaxisGeneticLimousinSkin

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Area of Science:

  • Veterinary Pathology
  • Animal Genetics
  • Dermatology

Background:

  • Dermatosparaxis, a connective tissue disorder causing extreme skin fragility, is analogous to Ehlers Danlos Syndrome in humans.
  • Two neonatal Limousin calves presented with severe congenital skin abnormalities and fissures.
  • This is the first documented case of dermatosparaxis in the Limousin cattle breed.

Purpose of the Study:

  • To report the first diagnosis of dermatosparaxis in pedigree Limousin calves.
  • To describe the clinical and pathological features of this severe, lethal phenotype.
  • To investigate the potential genetic basis of dermatosparaxis in this breed.

Main Methods:

  • Clinical examination and post-mortem evaluation of two affected Limousin calves.
  • Histopathological and electron microscopic examination of skin tissue.
  • Genetic testing to compare with known mutations in other cattle breeds.

Main Results:

  • Confirmed diagnosis of dermatosparaxis based on histological evidence of dysplastic dermal collagen.
  • Calves exhibited extreme skin fragility with multiple fissures and presented with a collapsed state.
  • Genetic analysis did not identify the previously described mutation found in Belgian Blue cattle; the specific cause remains unknown.

Conclusions:

  • This case represents the first report of dermatosparaxis in the Limousin breed, with a particularly severe phenotype.
  • Further genetic research is necessary to identify the causative mutation or genetic defect.
  • Increased awareness is crucial due to the breed's popularity and the lethal nature of this condition.