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Updated: Mar 13, 2026

Detection of Protein Aggregation using Fluorescence Correlation Spectroscopy
Published on: April 25, 2021
Organelle-specific bioprobes based on fluorogens with aggregation-induced emission (AIE) characteristics
1Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. cheliub@nus.edu.sg and Nanoscience and Nanotechnology Institute, National University of Singapore, 2 Engineering Drive 3, Singapore 117581, Singapore.
Abstract:
Bioprobes based on fluorogens with aggregation-induced emission (AIE) characteristics have been increasingly used in chemosensing and bioimaging due to their high sensitivity, photostability and biocompatibility. In this review, we summarize the design of cellular organelle specific (cytoplasm membrane, mitochondria, lysosomes, lipid droplets and nucleus) AIE bioprobes and their applications in organelle imaging, organelle bioactivity monitoring, and image-guided cancer cell ablation.
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