Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

4.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Timing is everything: outcomes of allogeneic HSCT in adults with inborn errors of immunity.

Bone marrow transplantation·2026
Same author

Outcome of treatment with trametinib in adults with histiocytic neoplasms in the United Kingdom.

British journal of haematology·2026
Same author

Impact of fludarabine dosage on outcomes in large B-cell lymphoma patients treated with CAR T-cell therapy: a retrospective study of the CTIWP of the EBMT.

Bone marrow transplantation·2026
Same author

Hemophagocytic Lymphohistiocytosis Triggered by <i>Legionella pneumophila</i> and SARS-CoV-2 Infection in GATA2 Deficiency.

Clinical case reports·2026
Same author

Results from the prospective phase 2 multicentre UK PBSC haplo trial using PTCy pre- or post-stem cells.

British journal of haematology·2026
Same author

Long-term MAPK inhibition of childhood refractory-Langerhans cell histiocytosis: an observational study of 288 patients.

Blood advances·2026

Related Experiment Video

Updated: Mar 13, 2026

Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols
08:31

Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols

Published on: October 18, 2016

14.4K

Monocyte, Macrophage, and Dendritic Cell Development: the Human Perspective.

Matthew Collin1, Venetia Bigley1

  • 1Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.

Microbiology Spectrum
|October 26, 2016
PubMed
Summary

Monocytes, macrophages, and dendritic cells (DCs) have complex developmental pathways. Recent research clarifies their origins, distinctions, and therapeutic potential in immune regulation.

More Related Videos

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

21.4K
Isolation of Human Monocytes by Double Gradient Centrifugation and Their Differentiation to Macrophages in Teflon-coated Cell Culture Bags
09:32

Isolation of Human Monocytes by Double Gradient Centrifugation and Their Differentiation to Macrophages in Teflon-coated Cell Culture Bags

Published on: September 9, 2014

71.2K

Related Experiment Videos

Last Updated: Mar 13, 2026

Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols
08:31

Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols

Published on: October 18, 2016

14.4K
Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

21.4K
Isolation of Human Monocytes by Double Gradient Centrifugation and Their Differentiation to Macrophages in Teflon-coated Cell Culture Bags
09:32

Isolation of Human Monocytes by Double Gradient Centrifugation and Their Differentiation to Macrophages in Teflon-coated Cell Culture Bags

Published on: September 9, 2014

71.2K

Area of Science:

  • Immunology and Cell Biology
  • Hematopoiesis and Immune Cell Development

Background:

  • Mononuclear phagocyte system maintenance involves intricate ontogeny and homeostasis.
  • Previous models of continuous renewal by blood monocytes are evolving.
  • Specialized dendritic cell (DC) development and macrophage self-renewal are recognized.

Purpose of the Study:

  • To clarify the complex developmental pathways of monocytes, macrophages, and dendritic cells (DCs).
  • To address challenges in studying cell development due to phenotype plasticity and hematopoiesis misconceptions.
  • To integrate new findings into a coherent understanding of myeloid mononuclear cell biology.

Main Methods:

  • Review and synthesis of recent research on monocyte, macrophage, and DC development.
  • Analysis of phenotype plasticity and hematopoiesis structures.
  • Cross-species comparisons for nomenclature standardization.

Main Results:

  • Distinction between inflammatory monocyte-derived DCs and steady-state DCs is clearer.
  • Conjoined lymphomyeloid hematopoiesis models accommodate shared DC phenotypes.
  • Standardized nomenclature for mammalian monocytes, macrophages, and DCs established through cross-species comparison.

Conclusions:

  • Understanding ontogeny and functional specialization provides insights into immune response regulation.
  • New therapeutic strategies for myeloid mononuclear cells are emerging.
  • The study refines our understanding of immune cell maintenance and function.