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Biodegradable and biomimetic elastomeric scaffolds for tissue-engineered heart valves
Yingfei Xue1, Vinayak Sant1, Julie Phillippi2
1Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Acta Biomaterialia
|October 27, 2016
Summary
Heart valve tissue engineering (HVTE) uses biomimetic elastomeric scaffolds to mimic native valve microenvironments. This review explores strategies for creating advanced scaffolds to improve current valve replacement therapies.
Area of Science:
- Biomaterials Science
- Cardiovascular Engineering
- Regenerative Medicine
Background:
- Valvular heart disease is a leading cause of cardiovascular death.
- Current valve replacements have limitations.
- Heart valve tissue engineering (HVTE) offers a promising alternative.
Purpose of the Study:
- To review strategies for engineering biomimetic elastomeric scaffolds for HVTE.
- To highlight approaches for recreating native heart valve microenvironments.
- To facilitate the clinical translation of functional HVTE constructs.
Main Methods:
- Discussed various biodegradable synthetic elastomers and their properties.
- Highlighted tissue engineering approaches to mimic native valve features.
- Focused on strategies for anisotropic architecture, mechanical properties, and biocompatibility.
Main Results:
- Synthetic biodegradable elastomers offer tunable properties for HVTE.
- Biomimetic design can recapitulate key features of the native valve microenvironment.
- Approaches exist to engineer scaffolds with desired characteristics.
Conclusions:
- Advanced biomimetic elastomeric scaffolds are crucial for successful HVTE.
- Further development is needed for clinical translation of synthetic elastomer-based HVTE.
- This review provides insights for designing next-generation HVTE constructs.
