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Case Report of a Patient Undergoing Peritoneal Dialysis with Encapsulating Peritoneal Sclerosis Superimposed With
Jun Li Tsai1, Ming Ju Wu2, Cheng Hsu Chen2
1Department of Family Medicine, Cheng Ching General Hospital, Taichung, Taiwan.
Introduction:
Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis (PD). Tamoxifen has been generally well-tolerated, even without randomized controlled trials.
Case Presentation:
Herein, we report a case of a patient undergoing 12 years of PD who developed EPS and calciphylaxis simultaneously. We also provide a comprehensive discussion about the association between EPS and calciphylaxis. Moreover, although tamoxifen is used in EPS due to its inhibition of fibroblast-transforming growth factor beta (TGFβ) production, it may worsen the calciphylaxis due to a hypercoagulable state.
Conclusions:
We suggest avoiding the use of tamoxifen for EPS in patients with superimposed calciphylaxis.
