Related Experiment Video
Updated: Mar 13, 2026
03:53
Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes
Published on: April 19, 2024
1.2K
Gut-lung axis: The microbial contributions and clinical implications.
Yang He1, Qu Wen1, Fangfang Yao1
1a Department of Cancer Center, Union Hospital , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
Critical Reviews in Microbiology
|October 27, 2016
Summary
The gut microbiome influences immune responses and disease development. This review explores the gut-lung axis, highlighting how gut and lung microbes impact disease progression and immune interactions.
Area of Science:
- Immunology
- Microbiology
- Gastroenterology
Background:
- The gut microbiome critically interacts with the host immune system, influencing disease development.
- Advances in understanding the respiratory immune system reveal host-microbiome interactions within the lung.
- A significant relationship exists between the gastrointestinal and respiratory tracts.
Purpose of the Study:
- To review the impact of gut and lung microbiota on disease exacerbation and progression.
- To elucidate the immunological connections within the gut-lung axis.
Main Methods:
- Literature review of existing research on gut-lung axis.
- Analysis of studies on microbial dysregulation in chronic diseases.
- Synthesis of immunological findings linking gut and lung environments.
Main Results:
- Microbial dysregulation in both gut and lung is linked to disease exacerbations.
- Shared conceptual features exist between chronic gut and lung diseases concerning microbial ecosystems.
- The gut-lung axis represents a key pathway for immune communication.
Conclusions:
- The gut-lung axis is crucial for understanding host-microbiome-immune interactions.
- Modulating gut and lung microbiota may offer therapeutic strategies for related diseases.
- Further research into the gut-lung axis can advance treatments for chronic inflammatory conditions.
More Related Videos
Related Concept Videos
01:20COPD: Pathogenesis and Clinical Features
2.1K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.1K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
5.0K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
5.0K
01:20Asthma: Pathogenesis and Management
1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
01:23Cystic Fibrosis: Pathogenesis
994
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
994
01:19Factors Affecting Pulmonary Ventilation
3.5K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
3.5K
01:23Anatomy of the Intestines
89.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
89.3K