Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Blood-brain Barrier00:49

The Blood-brain Barrier

54.5K
Overview
54.5K
Neuroplasticity01:01

Neuroplasticity

2.2K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.2K
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

789
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
789
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.4K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.4K
Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

5.0K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
5.0K
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

8.5K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
8.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-pharmacological interventions modulating immune response in Parkinson's disease: where do we stand for future preventive approaches.

Neurochemistry international·2026
Same author

HIV-1 late diagnosis: Strategies to overcome the misclassification of individuals acutely infected with HIV-1 as individuals diagnosed late.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2026
Same author

Lamotrigine, Contraceptives, and Psychiatry: A Narrative Review.

Cureus·2026
Same author

A dive into the untapped potential of marine compounds in counteracting neurodegeneration.

Pharmacology & therapeutics·2026
Same author

Emerging patterns in HIV integrase resistance.

AIDS (London, England)·2025
Same author

Urolithins and their phase II conjugates cross the blood-brain barrier and exert a stimulus-dependent anti-inflammatory effect on microglial cells by inhibiting NF-κB nuclear translocation.

Food & function·2025

Related Experiment Video

Updated: Mar 13, 2026

Orienteering as a Tool for Cognitive Research: An Implementation Guide
07:13

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

1.6K

Polyphenols Beyond Barriers: A Glimpse into the Brain.

Ines Figueira1, Regina Menezes1, Diana Macedo1

  • 1Instituto de Tecnologia Quimica e Biologica Antonio Xavier, Universidade Nova de Lisboa, Av. da Republica, 2780-157 Oeiras. Portugal.

Current Neuropharmacology
|October 28, 2016
PubMed
Summary

Plant polyphenols show neuroprotective potential, offering a promising avenue for healthy aging and preventing age-related brain diseases. Further research is needed to fully understand their nutritional and therapeutic benefits.

Keywords:
Bioavailabilityblood-brain barrierhealthy ageingneurodegenerative disordersneuroprotectionpolyphenols

More Related Videos

Author Spotlight: Applications of TEER Detection to Assess Cell Barrier Integrity
09:03

Author Spotlight: Applications of TEER Detection to Assess Cell Barrier Integrity

Published on: September 29, 2023

5.1K
Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
09:48

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

14.3K

Related Experiment Videos

Last Updated: Mar 13, 2026

Orienteering as a Tool for Cognitive Research: An Implementation Guide
07:13

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

1.6K
Author Spotlight: Applications of TEER Detection to Assess Cell Barrier Integrity
09:03

Author Spotlight: Applications of TEER Detection to Assess Cell Barrier Integrity

Published on: September 29, 2023

5.1K
Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
09:48

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

14.3K

Area of Science:

  • Nutritional Science
  • Neuroscience
  • Pharmacology

Background:

  • Aging is a complex process influenced by genetics and environment, with increasing life expectancy highlighting the need for strategies to maintain quality of life.
  • Plant polyphenols are extensively studied for their potential to prevent age-associated deterioration and diseases, particularly neurodegenerative conditions.
  • Research into dietary polyphenols' neuroprotective mechanisms involves in vitro, cell-based, animal, and human studies.

Purpose of the Study:

  • To review current research on the neuroprotective potential of plant polyphenols.
  • To highlight recent trends in the study of dietary polyphenols for brain health during aging.
  • To explore concepts such as polyphenol bioavailability and transport across the blood-brain barrier.

Main Methods:

  • Compilation of extensive and growing research in the field of plant polyphenols and neuroprotection.
  • Review of in vitro, cellular, animal studies, and human trials.
  • Exploration of key concepts including bioavailability, biotransformation, and transport across biological barriers.

Main Results:

  • Polyphenols demonstrate neuroprotective potential across various study models.
  • Key factors influencing efficacy, such as bioavailability and transport across the blood-brain barrier, are discussed.
  • Evidence suggests a beneficial impact of polyphenols on brain function during aging.

Conclusions:

  • Plant polyphenols offer a diverse and holistic approach for managing multifactorial diseases affecting cellular pathways.
  • While strong evidence supports their benefits for brain health in aging, underlying mechanisms require further consolidation.
  • Significant potential remains to be understood regarding the nutritional and pharmacological applications of dietary polyphenols for healthy aging.